HYALURONIC ACID MAY NOT PROTECT AGAINST EARLY CARTILAGE INJURY IN RUNNERS

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Investigators found increased T2 and T1 relaxation times in marathon runners, a finding which they noted demonstrated early cartilage injury. Intra-articular hyaluronic acid compared with normal saline did not significantly impact relaxation times in all knee areas. Researchers randomized 20 runners to receive either an intra-articular injection of hyaluronic acid (HA) or normal saline one week before they ran a marathon. There were 15 runners who completed the study, of which eight runners received HA and seven runners received normal saline. Investigators obtained baseline 3-T knee MRI prior to the marathon and at 48 to 72 hours, and three months after the marathon follow-up 3-T MRI scans were obtained. 

 

Investigators measured the T2 and T1 relaxation times of articular cartilage in eight locations which included the medial and lateral compartments and the patellofemoral joint. The changes in T2 and T1 relaxation times were compared between the treatment groups from baseline to immediate and 3-month post-marathon scans. Results showed that after the marathon, there were no gross morphologic MRI changes.

 

Source: Nathani A, et al. Am J Sports Med. 2019 via Healio.com


Courtesy of Barry Block, editor of PM News


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